What is quetiapine? Quetiapine is an antipsychotic medicine that is used to treat schizophrenia in adults and children who are at least 13 years old. Quetiapine is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old. Quetiapine is also used together with antidepressant medications to treat major depressive disorder in adults. Quetiapine may also be used for purposes not listed in this medication guide. Warnings Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Quetiapine is not approved for use in older adults with dementia-related psychosis. Before taking this medicine You should not use quetiapine if you are allergic to it. Quetiapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. Quetiapine is not approved for use by anyone younger than 10 years old. Tell your doctor if you have ever had: liver disease; heart problems; high or low blood pressure; low white blood cell (WBC) counts; abnormal thyroid tests or prolactin levels; constipation or urination problems; an enlarged prostate; a seizure; glaucoma or cataracts; high cholesterol or triglycerides; diabetes (in you or a family member); or trouble swallowing. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Taking antipsychotic medicine in the last 3 months of pregnancy may cause withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking quetiapine without your doctor's advice. quetiapine may temporarily affect fertility (your ability to have children) in women. You should not breastfeed while you are using quetiapine. How should I take quetiapine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. The longer you use quetiapine, the more likely you are to develop this disorder, especially if you are an older adult. Symptoms of this disorder include tremors or other uncontrollable muscle movements. You may take Seroquel with or without food. You should take Seroquel XR without food or with a light meal. Swallow the tablet whole and do not crush, chew, or break it. Quetiapine may cause you to have high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis. Drink plenty of liquids while you are taking quetiapine. Blood pressure may need to be checked often in a child or teenager taking quetiapine. You should not stop using quetiapine suddenly. Stopping suddenly may make your condition worse. This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use quetiapine. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of quetiapine can be fatal. What should I avoid while taking quetiapine? Avoid drinking alcohol. Dangerous side effects could occur. Avoid driving or hazardous activity until you know how quetiapine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise and in hot weather. You may be more prone to heat stroke. Quetiapine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); mask-like appearance of the face, trouble swallowing, problems with speech; a light-headed feeling, like you might pass out; severe constipation; painful or difficult urination; blurred vision, tunnel vision, eye pain, or seeing halos around lights; severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting; high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed. Common side effects may include: speech problems; dizziness, drowsiness, tiredness; lack of energy; fast heartbeats; stuffy nose; increased appetite, weight gain; upset stomach, vomiting, constipation; dry mouth; or problems moving. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect quetiapine? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Quetiapine can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Many drugs can affect quetiapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is quinapril? Quinapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Quinapril is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Quinapril is also used together with other medications to treat heart failure. Quinapril may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking quinapril and tell your doctor right away. You should not use quinapril if you have ever had angioedema. Do not take quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use quinapril together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use quinapril if you are allergic to it, or if: you have a history of angioedema; you recently took a heart medicine called sacubitril; or if you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, ramipril, or trandolapril. Do not take quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use quinapril together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking quinapril with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); liver disease; a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis; heart disease or congestive heart failure (unless you are taking quinapril for this condition); or if you are on a low-salt diet. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Quinapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Quinapril is not approved for use by anyone younger than 18 years old. How should I take quinapril? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking quinapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. If you need surgery, tell the surgeon ahead of time that you are using quinapril. You may need to stop using the medicine for a short time. If you are being treated for high blood pressure, keep using quinapril even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking quinapril? Drinking alcohol can further lower your blood pressure and may increase certain side effects of quinapril. Do not use salt substitutes or potassium supplements while taking quinapril, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Quinapril side effects Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; fast or pounding heartbeats, fluttering in your chest; little or no urination; pain or burning when you urinate; jaundice (yellowing of the skin or eyes); numbness, tingling, or burning pain in your hands or feet; fever, chills, cold or flu symptoms; high potassium--nausea, chest pain, irregular heartbeats, loss of movement; or low sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: headache; cough; or dizziness, tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Quinapril dosing information Usual Adult Dose for Hypertension: Initial dose: 10 or 20 mg orally once a day in patients not on diuretics Maintenance dose: 20 to 80 mg orally per day, administered as a single dose or in two equally divided doses Use: -Treatment of hypertension Usual Adult Dose for Congestive Heart Failure: Initial dose: 5 mg orally twice a day Maintenance dose: 20 to 40 mg orally per day administered in two equally divided doses Comments: -This dose may improve symptoms of heart failure, but increases in exercise duration have generally required higher doses. -If the initial dosage is well tolerated, patients should then be titrated at weekly intervals until an effective dose. Use: -Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis Usual Geriatric Dose for Congestive Heart Failure: 10 mg orally once a day Comments: Dose should be titrated the same way as for other adult patients. Uses: -Treatment of hypertension -Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis Usual Geriatric Dose for Hypertension: 10 mg orally once a day Comments: Dose should be titrated the same way as for other adult patients. Uses: -Treatment of hypertension -Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis   What other drugs will affect quinapril? Tell your doctor about all your other medicines, especially: lithium; a diuretic or "water pill"; gold injections to treat arthritis; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect quinapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and quinapril? Hydrochlorothiazide is a thiazide diuretic (water pill). Quinapril is in an ACE inhibitor (ACE stands for angiotensin converting enzyme). Hydrochlorothiazide and quinapril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Hydrochlorothiazide and quinapril may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and quinapril and tell your doctor right away. You should not use this medicine if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and quinapril together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or quinapril, or if: you have a history of angioedema; you are unable to urinate; you recently took a heart medicine called sacubitril; or you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril). Do not take hydrochlorothiazide and quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and quinapril together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and quinapril with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); cirrhosis or other liver disease; glaucoma; congestive heart failure; gout; lupus; an allergy to sulfa drugs or penicillin; or if you are on a low-salt diet. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Quinapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using hydrochlorothiazide and quinapril. Hydrochlorothiazide and quinapril is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and quinapril? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and quinapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. Your blood pressure will need to be checked often, and you may need occasional blood tests. If you need surgery, tell your surgeon you currently use this medicine. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking hydrochlorothiazide and quinapril? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and quinapril. Do not use salt substitutes or potassium supplements while taking this medicine, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Hydrochlorothiazide and quinapril side effects Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). You may be more likely to have an allergic reaction if you are African-American. Call your doctor at once if you have: a light-headed feeling, like you might pass out; blurred vision, tunnel vision, eye pain, or seeing halos around lights; swelling, weight gain, shortness of breath; sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, trouble swallowing; high potassium--nausea, tingly feeling, chest pain, irregular heartbeats, loss of movement; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low levels of sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: cough; headache, dizziness; tired feeling; or muscle pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and quinapril dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 12.5 to 25 mg-quinapril 10 to 20 mg orally once a day Comments: -The initial dosage of hydrochlorothiazide-quinapril should be based on the patient requirements for each drug individually.   What other drugs will affect hydrochlorothiazide and quinapril? Tell your doctor about all your other medicines, especially: any other blood pressure medication; lithium; everolimus, sirolimus, temsirolimus; an antibiotic--demeclocycline, doxycycline, minocycline, eravacycline, omadacycline, sarecycline, tetracycline; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and quinapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is rabeprazole? Rabeprazole is used short-term to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children who are at least 1 year old. Rabeprazole is used only in adults to treat conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome. Rabeprazole is also used in adults to promote healing of duodenal ulcers or erosive esophagitis (damage to your esophagus caused by stomach acid). Rabeprazole may also be given with an antibiotic to prevent duodenal ulcer caused by infection with Helicobacter pylori (H. pylori). Rabeprazole is not for immediate relief of heartburn symptoms. Rabeprazole may also be used for purposes not listed in this medication guide. Warnings Rabeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine. Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it. Rabeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight. You may be more likely to have a broken bone while taking rabeprazole long term or more than once per day. Before taking this medicine Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed. You should not use this medicine if you are allergic to rabeprazole or: if you also take any medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey); if you had breathing problems, kidney problems, or a severe allergic reaction after taking rabeprazole in the past; or if you are also allergic to medicines like rabeprazole, such as esomeprazole, lansoprazole, omeprazole, pantoprazole , Nexium, Prevacid, Prilosec, Protonix, and others. Tell your doctor if you have ever had: liver disease; osteoporosis or low bone mineral density (osteopenia); lupus (an autoimmune disorder); or low levels of magnesium in your blood. You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy. Tell your doctor if you are pregnant or breastfeeding. Do not give this medicine to a child without medical advice. Certain forms and strengths of rabeprazole should not be given to a child younger than 12 years old. How should I take rabeprazole? Rabeprazole is usually taken once per day. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Rabeprazole is for short-term use only, usually 4 to 8 weeks. Your doctor may recommend a second course of treatment if you need additional healing time. AcipHex Sprinkle should not be given to a child younger than 1 year old. Take rabeprazole with a full glass of water. If you take rabeprazole to treat duodenal ulcers, take the medicine after a meal. If you take rabeprazole to prevent ulcers caused by Helicobacter pylori, take the medicine with food. If you take rabeprazole for any other condition, you may take the medicine with or without food. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Swallow the tablet whole and do not crush, chew, or break it. Do not swallow a delayed-release capsule (AcipHex Sprinkle) whole. Open it and sprinkle the medicine into a spoonful of soft food such as applesauce, yogurt, or baby food made from fruit or vegetable. You may also mix the medicine with apple juice, Pedialyte, or infant formula. Swallow the mixture right away without chewing. Do not save it for later use. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using rabeprazole. Some conditions are treated with a combination of rabeprazole and antibiotics. Use all medications as directed. Take your medicines for the full prescribed length of time, even if your symptoms quickly improve. Call your doctor if your symptoms do not improve, or if they get worse while using rabeprazole. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking rabeprazole? rabeprazole can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine. Rabeprazole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; sudden pain or trouble moving your hip, wrist, or back; seizure (convulsions); kidney problems--fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, swelling, rapid weight gain; new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight; low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or signs of bleeding (if you also take warfarin)--headaches, dizziness, weakness; pain or swelling; bruising, unusual bleeding (nosebleeds, bleeding gums); red or pink urine; heavy menstrual flow; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or any bleeding that will not stop. Taking rabeprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk. If you use rabeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it. Common side effects may include: infection; pain; sore throat; headache; nausea, vomiting; gas, diarrhea, constipation; or stomach pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect rabeprazole? Tell your doctor about all your current medicines. Many drugs can affect rabeprazole, especially: an antibiotic such as clarithromycin or amoxicillin; digoxin; a diuretic or "water pill"; methotrexate; or warfarin (Coumadin, Jantoven). This list is not complete and many other drugs may affect rabeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is raloxifene? Raloxifene is used to treat osteoporosis in postmenopausal women. Raloxifene is not for use in men. Raloxifene may also be used for purposes not listed in this medication guide. Warnings raloxifene may increase your risk of a blood clot in your leg, your lung, or your eye. You should not take raloxifene if you have ever had this type of blood clot. Raloxifene can also increase your risk of a stroke, which can be fatal. This risk is highest if you have certain risk factors (such as smoking, having heart problems or high blood pressure, or if you have ever had a heart attack or a stroke). Although this medicine is for use only in postmenopausal women, you should not take raloxifene if you are pregnant or breastfeeding. Before taking this medicine This medicine may increase your risk of a blood clot in your leg, your lung, or your eye. You should not take raloxifene if you have ever had this type of blood clot. This medicine is for use only in women who can no longer get pregnant. Raloxifene can harm an unborn baby. Do not use if you are pregnant or may become pregnant. Do not breastfeed while taking raloxifene. Raloxifene can increase your risk of a stroke, which can be fatal. Tell your doctor if you have ever had: heart problems, irregular heartbeats; a heart attack or stroke, including "mini-stroke"; high blood pressure; cancer; or if you smoke. Tell your doctor if you have ever had: a blood clot; high triglycerides caused by using estrogen; liver or kidney disease; endometriosis; abnormal vaginal bleeding; or if you have not gone through menopause. How should I take raloxifene? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take the medicine at the same time each day, with or without food. If you need major surgery or will be on long-term bed rest, you will need to stop taking raloxifene at least 3 days ahead of time. You may not be able to restart the medicine until you are active again. Tell any doctor or surgeon who treats you that you take raloxifene. Raloxifene is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin D supplements. Follow your doctor's instructions very closely. Your doctor should check your progress on a regular basis. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking raloxifene? If you take calcium supplements, do not take more than your doctor has prescribed. Taking more calcium than recommended will not provide extra protection for your bones, and may cause serious side effects including kidney stones. Avoid sitting still for long periods of time during travel while you are taking raloxifene. Raloxifene side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using raloxifene and call your doctor at once if you have: swelling, tenderness, or other changes in your breasts; signs of a stroke--sudden numbness or weakness (especially on one side of the body), slurred speech, vision problems; signs of a blood clot in the lung--chest pain, trouble breathing, coughing up blood; or signs of a blood clot deep in the body--swelling, warmth, or redness in an arm or leg. Common side effects may include: hot flashes; leg cramps; swelling in your hands, feet, or ankles; joint pain; flu symptoms; or increased sweating. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Raloxifene dosing information Usual Adult Dose for Osteoporosis: 60 mg orally per day Comments: -For treatment or prevention of osteoporosis, advise patients to add supplemental calcium and/or vitamin D if daily intake is inadequate. -When this drug is used to reduce the risk of invasive breast cancer, the optimum duration of treatment is not known. Uses: -Treatment and prevention of osteoporosis in postmenopausal women. -Reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis and/or at high risk of invasive breast cancer. Usual Adult Dose for Prevention of Osteoporosis: 60 mg orally per day Comments: -For treatment or prevention of osteoporosis, advise patients to add supplemental calcium and/or vitamin D if daily intake is inadequate. -When this drug is used to reduce the risk of invasive breast cancer, the optimum duration of treatment is not known. Uses: -Treatment and prevention of osteoporosis in postmenopausal women. -Reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis and/or at high risk of invasive breast cancer. Usual Adult Dose for Prevention of Breast Cancer: 60 mg orally per day Comments: -For treatment or prevention of osteoporosis, advise patients to add supplemental calcium and/or vitamin D if daily intake is inadequate. -When this drug is used to reduce the risk of invasive breast cancer, the optimum duration of treatment is not known. Uses: -Treatment and prevention of osteoporosis in postmenopausal women. -Reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis and/or at high risk of invasive breast cancer.   What other drugs will affect raloxifene? Tell your doctor about all your other medicines, especially: cholestyramine; warfarin (Coumadin, Jantoven); or birth control pills or hormone replacement therapy. This list is not complete. Other drugs may affect raloxifene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is ramipril? Ramipril (Altace) is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Ramipril is used to treat high blood pressure (hypertension) or congestive heart failure, and to improve survival after a heart attack. Ramipril may also be used for purposes not listed in this medication guide. Warnings Do not use ramipril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. You should not use ramipril if you have ever had angioedema. Do not take this medicine within 36 hours before or after taking medicine that contains sacubatril (such as Entresto). If you have diabetes, do not use ramipril together with any medication that contains aliskiren (such as Tekturna or Tekamlo). Before taking this medicine You should not use ramipril if you are allergic to it, or if: you have a history of angioedema; you recently took a heart medicine called sacubatril; or if you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, or trandolapril. Do not take ramipril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto). If you have diabetes, do not use ramipril together with any medication that contains aliskiren (such as Tekturna or Tekamlo). You may also need to avoid taking ramipril with aliskiren if you have kidney disease. To make sure this medicine is safe for you, tell your doctor if you have ever had: kidney disease (or if you are on dialysis); liver disease; a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis; or if you are also taking telmisartan (Micardis). Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Ramipril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control. It is not known whether ramipril passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take ramipril? Take ramipril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. Ramipril can be taken with or without food. Swallow the tablet whole. You may open the capsule and sprinkle the medicine into a half-cup (4 ounces) of water, apple juice, or applesauce to make swallowing easier. Swallow without chewing. You may store the mixture for up to 24 hours at room temperature, or up to 48 hours in a refrigerator. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking ramipril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. Your blood pressure will need to be checked often, and you may need frequent blood tests to check your potassium levels. Drink plenty of water each day while you are taking this medication. If you need surgery, tell the surgeon ahead of time that you are using this medicine. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid? Do not use salt substitutes or potassium supplements while taking ramipril, unless your doctor has told you to. Avoid drinking alcohol. It can further lower your blood pressure and may increase some of the side effects of ramipril. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Ramipril side effects Get emergency medical help if you have any signs of an allergic reaction to ramipril: hives; severe stomach pain; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; jaundice (yellowing of your skin or eyes); little or no urination; fever, chills, sore throat, cold or flu symptoms; or high potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common ramipril side effects may include: headache; cough; or dizziness, weakness, tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is ranolazine? Ranolazine is used to treat chronic angina (chest pain). Ranolazine is not for use during an acute (emergency) attack of angina. Ranolazine may also be used for purposes not listed in this medication guide. Warnings You should not take ranolazine if you have cirrhosis of the liver. Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together. Before taking this medicine You should not take ranolazine if you are allergic to it, or if you have: cirrhosis of the liver. Many drugs can interact and cause dangerous effects. Some drugs should not be used together with ranolazine. Your doctor may change your treatment plan if you also use: clarithromycin; nefazodone; St. John's wort; antifungal medicine--itraconazole, ketoconazole; HIV or AIDS medicine--indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir; seizure medicine--carbamazepine, phenobarbital, phenytoin; or tuberculosis medicine--rifabutin, rifampin, rifapentine. Tell your doctor if you have ever had: long QT syndrome (in you or a family member); liver disease; or kidney disease. Tell your doctor if you are pregnant or breastfeeding. How should I take ranolazine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take ranolazine with or without food. Swallow the tablet whole and do not crush, chew, or break it. Chronic angina is often treated with a combination of drugs. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Call your doctor if your symptoms do not improve, or if they get worse. You will need frequent medical tests to check your heart and kidney function. Store at room temperature away from moisture and heat. What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause nausea, vomiting, numbness or tingling, dizziness, double vision, confusion, or fainting. What should I avoid while taking ranolazine? Avoid driving or hazardous activity until you know how ranolazine will affect you. Your reactions could be impaired. Grapefruit may interact with ranolazine and lead to unwanted side effects. Avoid the use of grapefruit products. Ranolazine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; fast or pounding heartbeats, fluttering in your chest; or kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath. Common side effects may include: nausea, constipation; headache; or dizziness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Ranolazine dosing information Usual Adult Dose for Angina Pectoris: 500 mg orally twice a day; increase to 1000 mg orally twice a day as needed Maximum dose: 1000 mg orally twice a day Use: Treatment of chronic angina   What other drugs will affect ranolazine? Tell your doctor about all your current medicines. Many drugs can affect ranolazine, especially: any other medicine to treat heart disease; an antibiotic or antifungal medicine; cholesterol-lowering medicine; oral diabetes medicine; medicine to prevent organ transplant rejection; medicine to treat a mental illness; or medicine to treat or prevent nausea and vomiting caused by chemotherapy or radiation. This list is not complete and many other drugs may affect ranolazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is rasagiline? Rasagiline is used to treat symptoms of Parkinson's disease (stiffness, tremors, spasms, poor muscle control). Rasagiline is sometimes used with another medicine called levodopa. Rasagiline may also be used for purposes not listed in this medication guide. Warnings Tell your doctor about all medicines you have used in the 2-week period before you start taking rasagiline. Many drugs can interact with rasagiline, and some drugs should not be used together. Before taking this medicine You should not take rasagiline if you are allergic to it. Do not use rasagiline if you have used any other MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, selegiline, tranylcypromine, and others. Many drugs can interact and cause dangerous effects. Some drugs should not be used together with rasagiline. Your doctor may change your treatment plan if you also use: cyclobenzaprine (a muscle relaxer); dextromethorphan (contained in many over-the-counter cough medicines); meperidine (Demerol); methadone; St. John's wort; or tramadol (Ultram, Ultracet). Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with rasagiline and cause a serious condition called serotonin syndrome. Tell your doctor if you have ever had: high or low blood pressure; liver or kidney disease; or if you take ciprofloxacin (an antibiotic). People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for. Tell your doctor if you are pregnant or breastfeeding. How should I take rasagiline? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. If you take rasagiline alone, your dose may be different than if you take rasagiline with other Parkinson's medications. Follow your doctor's dosing instructions very carefully. Rasagiline may be only part of a complete program of treatment that also includes a special diet. Follow the diet plan created for you by your doctor or nutrition counselor. Get familiar with the list of foods you should avoid to help prevent certain side effects of rasagiline. Call your doctor if your Parkinson's symptoms do not improve, or if they get worse while using rasagiline. Store at room temperature away from moisture and heat. Do not stop using rasagiline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using rasagiline. What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of rasagiline can be fatal. Overdose symptoms may include drowsiness, dizziness, severe headache, rapid pulse, feeling agitated or irritable, muscle spasms in your neck or jaw, sweating, cold or clammy skin, shallow breathing, fainting, or seizure (convulsions). These symptoms may be delayed for 12 to 24 hours after an overdose. What should I avoid while taking rasagiline? Avoid driving or hazardous activity until you know how rasagiline will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid drinking alcohol, especially red wine, vermouth, and tap beers or ale. Also avoid eating foods that are high in tyramine, such as aged cheeses, fava beans, soy sauce, herring, pickled or processed meats and fish, and meats that are aged, dried, smoked, or fermented. Eating tyramine while you are taking rasagiline can raise your blood pressure to dangerous levels which could cause life-threatening side effects. Rasagiline side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe headache, blurred vision, pounding in your neck or ears; extreme drowsiness or falling asleep suddenly, even after feeling alert; unusual changes in mood or behavior; hallucinations; a light-headed feeling, like you might pass out; or worsening symptoms of Parkinson's disease (especially uncontrolled muscle movements). Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Some people taking rasagiline with levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Common side effects may include: depressed mood; sleep problems (insomnia), strange dreams; involuntary muscle movements; loss of appetite, weight loss; indigestion, stomach pain, nausea, vomiting, constipation; joint pain or stiffness; rash; cough or other flu symptoms; dry mouth; or swelling in your hands or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Rasagiline side effects (more detail) Rasagiline dosing information Usual Adult Dose for Parkinson's Disease: Monotherapy: Recommended dose: 1 mg orally once a day Adjunct therapy: Initial dose (in patients on concomitant levodopa): 0.5 mg orally once a day Initial dose (in patients not on concomitant levodopa): 1 mg orally once a day Maintenance dose: 0.5 mg to 1 mg orally once a day Maximum dose: 1 mg orally once a day Comments: May be used as adjunct therapy in patients on levodopa therapy, with or without other drugs used in the treatment of Parkinson's disease. Detailed Rasagiline dosage information What other drugs will affect rasagiline? Using rasagiline with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor if you have taken an antidepressant during the 2-week period before you start taking rasagiline. Many drugs can affect rasagiline, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is repaglinide? Repaglinide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. repaglinide is not for treating type 1 diabetes. Repaglinide may also be used for purposes not listed in this medication guide. Warnings You should not use repaglinide if you have type 1 diabetes, severe liver disease, or diabetic ketoacidosis. You should not use repaglinide together with gemfibrozil or NPH insulin (such as isophane insulin). Before taking this medicine You should not use repaglinide if you are allergic to it, or if you have: severe liver disease; or diabetic ketoacidosis (call your doctor for treatment). Many drugs can interact with repaglinide and some drugs should not be used at the same time. Your doctor may change your treatment plan if you also use: clopidogrel; cyclosporine; gemfibrozil; or NPH insulin (such as isophane insulin). Tell your doctor if you have ever had: liver disease; or if you also take metformin or other diabetes medicines. Follow your doctor's instructions about using repaglinide if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. You should not breastfeed while using repaglinide. Repaglinide is not approved for use by anyone younger than 18 years old. How should I take repaglinide? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Repaglinide is usually taken 2 to 4 times daily, within 30 minutes before eating a meal. Follow your doctor's instructions. If you skip a meal, do not take your dose of repaglinide. Wait until your next meal. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda). Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency. Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination. Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule. Repaglinide is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely. Store repaglinide at room temperature away from moisture and heat. What happens if I miss a dose? Take your dose as soon as you can, but only if you are getting ready to eat a meal. If you skip a meal, skip the missed dose and wait until your next meal. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A repaglinide overdose can cause life-threatening hypoglycemia. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions). What should I avoid while taking repaglinide? Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment. Repaglinide side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Call your doctor at once if you have: pale or yellowed skin, dark colored urine, fever, confusion or weakness; or pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting. Common side effects may include: low blood sugar; nausea, diarrhea; headache, back pain; joint pain; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Repaglinide dosing information Usual Adult Dose for Diabetes Type 2: Individualize therapy: Dose preprandially 2, 3, or 4 times a day -For patients not previously treated with antidiabetic agents or whose glycosylated hemoglobin (HbA1c) is less than 8%: Initial dose: 0.5 mg orally with each meal -For patients previously treated with antidiabetic agents or whose HbA1c is 8% or higher: Initial dose: 1 or 2 mg orally with each meal Dose Adjustments: Based upon blood glucose response, double the preprandial dose up to a maximum meal time dose of 4 mg until satisfactory glycemic response is achieved; allow at least 1 week to assess response after each dose adjustment. Recommended Dose Range: 0.5 to 4 mg orally with each meal Maximum Daily Dose: 16 mg per day Comments: -Fasting blood glucose concentrations are generally used to adjust doses, however, postprandial glucose levels may be used in patients whose pre-meal blood glucose levels are satisfactory but whose overall glycemic control (HbA1c) is inadequate. -When hypoglycemia occurs in patients taking this drug in combination with a thiazolidinedione or metformin, the dose of this drug should be reduced. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.   What other drugs will affect repaglinide? Many other medicines that can increase or decrease the effects of repaglinide on lowering your blood sugar. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is risedronate? Risedronate is used to treat osteoporosis caused by menopause, or steroid use. risedronate is for use when you have a high risk of bone fracture due to osteoporosis. Risedronate is also used to treat Paget's disease of bone. Risedronate may also be used for purposes not listed in this medication guide. Warnings You should not take risedronate if you have problems with your esophagus, or low levels of calcium in your blood. Do not take risedronate if you cannot sit upright or stand for at least 30 minutes after taking the medicine. Risedronate can cause serious problems in the stomach or esophagus. Stop using risedronate and call your doctor at once if you have chest pain, new or worsening heartburn, or pain when swallowing. Also call your doctor if you have muscle spasms, numbness or tingling (in hands and feet or around the mouth), new or unusual hip pain, or severe pain in your joints, bones, or muscles. Before taking this medicine You should not take risedronate if you are allergic to it, or if you have: low levels of calcium in your blood (hypocalcemia); or problems with the muscles in your esophagus (the tube that connects your mouth and stomach). Do not take risedronate if you cannot sit upright or stand for at least 30 minutes. Risedronate can cause serious problems in the stomach or esophagus. You must stay upright for at least 30 minutes after taking risedronate. Tell your doctor if you have ever had: trouble swallowing; problems with your stomach or digestion; hypocalcemia; a dental problem (you may need a dental exam before you begin taking risedronate); kidney disease; or any condition that makes it hard for your body to absorb nutrients from food (malabsorption). This medicine may cause jaw bone problems (osteonecrosis). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Ask your doctor about your own risk. Talk with your doctor about the risks and benefits of using this medication. It is not known whether this medicine will harm an unborn baby. Stop taking risedronate and tell your doctor right away if you become pregnant, or think you may be pregnant. You should not breastfeed while using risedronate. Risedronate should not be given to a child younger than 18 years old. How should I take risedronate? Risedronate tablets come in different strengths (number of milligrams per pill) that are taken on different schedules. You may need to take a tablet once per day, once per week, once per month, or for 2 days in a row once per month. Your dosing schedule will depend on why you are taking risedronate and in what tablet strength. If you change strengths, you may also need to change your schedule. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Risedronate is often given for only 3 to 5 years. Take the Actonel tablet first thing in the morning with a full glass (6 to 8 ounces) of water, at least 30 minutes before you eat or drink anything or take any other medicine. Take the Atelvia tablet just after breakfast, with at least 4 ounces of water. Use only plain water when taking a risedronate tablet. Do not use coffee, tea, soda, juice, or mineral water. Do not crush, chew, or suck on a risedronate tablet. Swallow it whole. For at least 30 minutes after taking risedronate: Do not lie down or recline. Do not take any other medicine including vitamins, calcium, iron, antacids, or laxatives. Take this medicine at the same time each day or on the same day each week or each month (depending on your dosing schedule). Pay special attention to your dental hygiene while taking risedronate. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using risedronate. Risedronate is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor's instructions very closely. Store at room temperature away from moisture and heat. Keep unused effervescent tablets in the foil blister pack.   What happens if I miss a dose? Once-daily dosing: If you forget to take risedronate first thing in the morning, do not take it later in the day. Wait until the following morning and skip the missed dose. Do not take two (2) doses in one day. Once-per-week or once-per-month dosing: If you forget to take risedronate on your scheduled day, take it first thing in the morning on the day after you remember the missed dose. Then return to your regular weekly or monthly schedule on your chosen dose day. Do not take 2 doses in one day. Call your doctor for instructions if you miss more than 2 doses in a month. What happens if I overdose? Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down. What should I avoid while taking risedronate? Do not take two different brands or strengths of risedronate at the same time. Avoid taking any other medicines for at least 30 minutes after taking risedronate. This includes vitamins, calcium, iron, antacids, or laxatives. Some medicines can make it harder for your body to absorb risedronate. Avoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely. Avoid drinking large amounts of alcohol. Heavy drinking can also cause bone loss. Risedronate side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Stop using risedronate and call your doctor at once if you have: chest pain, new or worsening heartburn; difficulty or pain when swallowing; pain or burning under the ribs or in the back; severe heartburn, burning pain in your upper stomach, or coughing up blood; new or unusual pain in your thigh or hip; jaw pain, numbness, or swelling; severe joint, bone, or muscle pain; or low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Common side effects may include: heartburn, diarrhea, indigestion; stomach pain; back pain, joint pain, muscle pain; or flu-like symptoms. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect risedronate? Tell your doctor about all your other medicines, especially: aspirin; calcium or iron supplements; antacids, laxatives; or NSAIDs (nonsteroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect risedronate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is risperidone? Risperidone is an antipsychotic medicine that works by changing the effects of chemicals in the brain. Risperidone is used to treat schizophrenia in adults and children who are at least 13 years old. Risperidone is also used to treat symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old. Risperidone is also used to treat symptoms of irritability in autistic children who are 5 to 16 years old. Warnings Risperidone is not approved for use in older adults with dementia-related psychosis. Do not give risperidone to a child without a doctor's advice. While you are taking this medicine, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking this medication. Risperidone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of this medicine. Stop using this medicine and call your doctor at once if you have fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, restless muscle movements in your face or neck, tremor (uncontrolled shaking), trouble swallowing, feeling light-headed, or fainting. Before taking this medicine You should not use risperidone if you are allergic to it. Risperidone may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. To make sure this medicine is safe for you, tell your doctor if you have ever had: heart disease, high blood pressure, heart rhythm problems, stroke or heart attack; diabetes (or risk factors such as obesity or family history of diabetes); low white blood cell (WBC) counts; liver or kidney disease; seizures; breast cancer; low bone mineral density; trouble swallowing; Parkinson's disease; or if you are dehydrated. The risperidone orally disintegrating tablet may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking risperidone, do not stop taking it without your doctor's advice. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of risperidone on the baby. This medicine may temporarily affect fertility (ability to have children) in women. Risperidone can pass into breast milk and may cause side effects in the baby. If you breast-feed while using this medicine, tell your doctor if the baby has symptoms such as drowsiness, tremors, or involuntary muscle movements. Do not give this medicine to a child without a doctor's advice. How should I take risperidone? Take risperidone exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Risperidone can be taken with or without food. Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Do not mix the liquid medicine with cola or tea. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Store at room temperature away from moisture, heat, and light. Do not liquid medicine to freeze.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe drowsiness, fast heart rate, feeling light-headed, fainting, and restless muscle movements in your eyes, tongue, jaw, or neck. What to avoid Avoid driving or hazardous activity until you know how risperidone will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries. Avoid drinking alcohol. Dangerous side effects could occur. While you are taking risperidone, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. Risperidone side effects Get emergency medical help if you have signs of an allergic reaction to risperidone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); breast swelling or tenderness (in men or women), nipple discharge, impotence, lack of interest in sex, missed menstrual periods; severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out; low white blood cells - sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; low levels of platelets in your blood - easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; or penis erection that is painful or lasts 4 hours or longer. Common risperidone side effects may include: headache; dizziness, drowsiness, feeling tired; tremors, twitching or uncontrollable muscle movements; agitation, anxiety, restless feeling; depressed mood; dry mouth, upset stomach, diarrhea, constipation; weight gain; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect risperidone? Taking risperidone with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: blood pressure medication; carbamazepine; clozapine; fluoxetine (Prozac) or paroxetine (Paxil); or levodopa. This list is not complete. Other drugs may interact with risperidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is rivastigmine? Rivastigmine is used to treat mild to moderate dementia caused by Alzheimer's or Parkinson's disease. Rivastigmine is not a cure for Alzheimer's or Parkinson's disease. Rivastigmine may also be used for purposes not listed in this medication guide. Warnings You should not take oral rivastigmine if you have ever had severe redness, itching, or skin irritation caused by wearing a rivastigmine transdermal skin patch. Before taking this medicine You should not take rivastigmine if you are allergic to rivastigmine or similar medicines, such as felbamate, meprobamate, or carisoprodol. You should not take oral rivastigmine if you have ever had severe redness, itching, or skin irritation caused by wearing a rivastigmine transdermal skin patch. Tell your doctor if you have ever had: an ulcer or stomach bleeding; a seizure; heart problems; liver or kidney disease; urination problems; or asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. How should I take rivastigmine? Do not wear a rivastigmine transdermal skin patch at the same time you are taking rivastigmine capsules or oral liquid. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take rivastigmine with food. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). You may swallow the liquid medicine directly from the syringe or mix the medicine with a small glass of water, fruit juice, or soda. Stir and drink this mixture within 4 hours after mixing. Add a little more water to the glass, swirl gently and drink right away. After using the syringe, wipe the outside of it with a clean tissue and put the syringe back into its protective case. Close the medicine bottle using the child-resistant closure. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking rivastigmine. Rivastigmine doses are based on weight. Your dose needs may change if you gain or lose weight. If you need surgery, tell your surgeon you currently use this medicine. If you stop taking rivastigmine for any reason, do not restart the medicine without talking to your doctor first. You may need to start with a lower dose. Store in an upright position at room temperature, away from moisture and heat. Do not allow the liquid medicine to freeze. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. If you miss several doses in a row, call your doctor before taking any more of rivastigmine. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe nausea, vomiting, salivation, sweating, slow heartbeats, weak or shallow breathing, fainting, or seizure (convulsions). What should I avoid while taking rivastigmine? Avoid driving or hazardous activity until you know how rivastigmine will affect you. Your reactions could be impaired. Rivastigmine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe or ongoing vomiting or diarrhea, loss of appetite, weight loss; bloody or tarry stools, cough with bloody mucus or vomit that looks like coffee grounds; a light-headed feeling, like you might pass out; tremors (uncontrolled shaking), restless muscle movements in your eyes, tongue, jaw, or neck; seizure (convulsions); painful or difficult urination; severe skin redness, itching, or irritation; or dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin. Common side effects may include: upset stomach, nausea, vomiting; loss of appetite; or weakness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Rivastigmine dosing information Usual Adult Dose for Alzheimer's Disease: MILD TO MODERATE ALZHEIMER'S DISEASE: ORAL: -Initial dose: 1.5 mg orally twice a day -Maintenance dose: After a minimum of 2 weeks of treatment, if the initial dosage is well tolerated, it can be increased to 3 mg twice a day; subsequent increases to 4.5 mg and 6 mg twice a day should be attempted only after a minimum of 2 weeks at the previous dosage TRANSDERMAL PATCH: -Initial Dose: 4.6 mg/24 hour patch applied to the skin once daily -Maintenance Dose: After a minimum of 4 weeks of treatment at the initial dose, and if well tolerated, the dose can be increased to 9.5 mg/24 hours for as long as this dose is beneficial; the dose can then be increased to 13.3 mg/24 hours -Maximum Dose: 13.3 mg/24 hour patch applied to skin daily; higher doses confer no appreciable additional benefit, and are associated with significant increase in the incidence of adverse events SEVERE ALZHEIMER'S DISEASE: TRANSDERMAL PATCH: -Recommended dose: 13.3 mg/24 hours transdermal patch applied to skin once daily; replace with a new patch every 24 hours Use: For the treatment of mild, moderate, or severe dementia of the Alzheimer's type (AD) Usual Adult Dose for Parkinson's Disease: MILD TO MODERATE PARKINSON'S DISEASE DEMENTIA: ORAL: Initial dose: 1.5 mg orally twice a day with morning and evening meals Maintenance dose: Subsequently, the dose can be increased to 3 mg orally twice a day and further to 4.5 mg twice a day and 6 mg twice a day (based on tolerability) with a minimum of 4 weeks at each dose TRANSDERMAL PATCH: Initial dose: 4.6 mg/24 hours applied to the skin once a day Maintenance dose: After a minimum of four weeks of treatment and if well tolerated, the dose of the patch can be increased to 9.5 mg/24 hours for as long as this dose is beneficial. The dose can then be increased to 13.3 mg/24 hours. Maximum dose: 13.3 mg/24 hours. Higher doses confer no appreciable additional benefit, and are associated with significant increase in the incidence of adverse events. Use: For the treatment of mild to moderate dementia associated with Parkinson's disease   What other drugs will affect rivastigmine? Tell your doctor about all your other medicines, especially: medicine to treat depression, anxiety, mood disorders, or mental illness; cold or allergy medicine (Benadryl and others); beta blocker heart or blood pressure medication; medicine to treat Parkinson's disease; medicine to treat nausea/vomiting, stomach problems, motion sickness, or irritable bowel syndrome; medicine to treat overactive bladder; bronchodilator asthma medication; or an NSAID (nonsteroidal anti-inflammatory drug such as aspirin, ibuprofen, naproxen, Advil, Motrin, Aleve, and others. This list is not complete and many other drugs may affect rivastigmine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is rizatriptan? Rizatriptan is a headache medicine that narrows the blood vessels around the brain. Rizatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Rizatriptan is used to treat migraine headaches. Rizatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Rizatriptan should not be used to treat a common tension headache, or a headache that causes loss of movement on one side of your body. Use rizatriptan only if your condition has been confirmed by a doctor as migraine headaches. Rizatriptan may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if you have uncontrolled high blood pressure, heart problems, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Do not take rizatriptan within 24 hours before or after using another migraine headache medicine. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Before taking this medicine You should not use rizatriptan if you are allergic to it, or if you have: heart problems, or a stroke (including "mini-stroke"); coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart; circulation problems affecting your legs, arms, stomach, intestines, or kidneys; uncontrolled high blood pressure; severe liver disease; or a headache that seems different from your usual migraine headaches. Do not use rizatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: liver or kidney disease; heart problems, chest pain; shortness of breath; or risk factors for coronary artery disease (such as high blood pressure, high cholesterol, diabetes, menopause, smoking, a family history of coronary artery disease, being overweight, or being older than 40 and a man). Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with rizatriptan and cause a serious condition called serotonin syndrome. Rizatriptan disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). Tell your doctor if you are pregnant or breastfeeding. Rizatriptan is not approved for use by anyone younger than 6 years old. How should I use rizatriptan? Take rizatriptan as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Take the regular tablet whole with a full glass of water. Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves. After taking a tablet (for adults): If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. If your symptoms have not improved, contact your doctor before taking any more tablets. After taking a tablet (for children ages 6 to 17): If your headache does not completely go away, or goes away and comes back, contact your doctor before taking any more tablets. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Call your doctor if your symptoms do not improve, or if you have more than 4 headaches in one month (30 days). Rizatriptan can raise blood pressure to dangerous levels. Your blood pressure may need to be checked often while you are using rizatriptan. If you use rizatriptan long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Store at room temperature away from moisture and heat. What happens if I miss a dose? Since rizatriptan is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using this medicine. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using rizatriptan? Do not take rizatriptan within 24 hours before or after using another migraine headache medicine, including: almotriptan, eletriptan, frovatriptan, naratriptan, sumatriptan, zolmitriptan; or ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine. Avoid driving or hazardous activity until you know how rizatriptan will affect you. Your reactions could be impaired. Rizatriptan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using rizatriptan and call your doctor at once if you have: sudden and severe stomach pain and bloody diarrhea; cold feeling or numbness in your feet and hands; severe headache, blurred vision, pounding in your neck or ears; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Common side effects may include: dizziness, drowsiness, feeling tired; or pain or a feeling of pressure in your throat or chest. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Rizatriptan dosing information Usual Adult Dose for Migraine: Use only after a clear diagnosis of migraine has been established Initial dose: 5 mg or 10 mg orally, once -Provided there has been a response to first dose, a second dose may be administered at least 2 hours later if migraine returns Maximum dose: 30 mg in a 24-hour period Comments: -The 10 mg dose may provide greater effect, however there may be a greater risk of adverse reactions. -This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke. -The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established; the effectiveness of a second dose or subsequent doses has not been established in placebo-controlled trials. Use: For the acute treatment of migraine with or without aura. Usual Pediatric Dose for Migraine: Use only after a clear diagnosis of migraine has been established 6 years or older and weight less than 40 kg: -Initial dose: 5 mg orally once 6 years or older and weight 40 kg or greater: -Initial dose: 10 mg orally once Maximum: 1 dose in any 24-hour period Comments: -This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke. -The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established; the safety and effectiveness of more than 1 dose within 24 hours has not been established. Use: For the acute treatment of migraine with or without aura in patients 6 years or older.   What other drugs will affect rizatriptan? Tell your doctor about all your other medicines, especially: propranolol; an antidepressant; or medicine to treat a mood disorder. This list is not complete. Other drugs may affect rizatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. Tell your doctor about all your other medicines, especially any type of antidepressant. Other drugs may affect rizatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is ropinirole? Ropinirole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Ropinirole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Ropinirole is also used to treat restless legs syndrome (RLS). Only immediate-release ropinirole (Requip) is approved to treat either Parkinson symptoms or RLS. Extended-release ropinirole (Requip XL) is approved only to treat Parkinson symptoms. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition. Ropinirole may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use ropinirole if you are allergic to it. To make sure ropinirole is safe for you, tell your doctor if you have: high or low blood pressure; kidney disease (or if you are on dialysis); heart disease, heart rhythm problems; a sleep disorder such as narcolepsy, or other conditions that may cause daytime sleepiness; or if you smoke. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether ropinirole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether ropinirole passes into breast milk or if it could affect the nursing baby. Ropinirole may slow breast milk production. Tell your doctor if you are breast-feeding. Ropinirole is not approved for use by anyone younger than 18 years old. How should I take ropinirole? Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you are taking immediate-release ropinirole (Requip) you should not take extended-release ropinirole (Requip XL) at the same time. The dose and timing of ropinirole in treating Parkinson's disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label. Ask your pharmacist if you have any questions about the kind of ropinirole you receive at the pharmacy. Ropinirole can be taken with or without food. Take the medicine at the same time each day. Do not crush, chew, or break an extended-release tablet (Requip XL). Swallow it whole. Call your doctor if you see part of the ropinirole tablet in your stool. This is a sign that your body may not have absorbed all of the medicine. If you are taking this medicine for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Do not stop using ropinirole suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking ropinirole? Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Dizziness may impair your thinking or reactions. Avoid driving or operating machinery until you know how ropinirole will affect you. Drinking alcohol can increase certain side effects of ropinirole. Ropinirole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Some people taking ropinirole have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Call your doctor at once if you have: extreme drowsiness, falling asleep suddenly (even after feeling alert); worsening or no improvement in your symptoms; a light-headed feeling, like you might pass out; unusual changes in mood or behavior; tremors, twitching uncontrollable muscle movements; or hallucinations (seeing or hearing things that are not real). Side effects such as confusion or hallucinations may be more likely in older adults. Common side effects may include: drowsiness, dizziness, weakness; headache, confusion, hallucinations; increased blood pressure (severe headache, pounding in your neck or ears, nosebleed, irregular heartbeats); nausea, vomiting, upset stomach, constipation; flu symptoms (fever, chills, body aches); sudden muscle movements; increased sweating; or swelling in your legs or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect ropinirole? Taking ropinirole with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures. Other drugs may interact with ropinirole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is ropinirole? Ropinirole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Ropinirole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Ropinirole is also used to treat restless legs syndrome (RLS). Only immediate-release ropinirole (Requip) is approved to treat either Parkinson symptoms or RLS. Extended-release ropinirole (Requip XL) is approved only to treat Parkinson symptoms. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition. Ropinirole may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use ropinirole if you are allergic to it. To make sure ropinirole is safe for you, tell your doctor if you have: high or low blood pressure; kidney disease (or if you are on dialysis); heart disease, heart rhythm problems; a sleep disorder such as narcolepsy, or other conditions that may cause daytime sleepiness; or if you smoke. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether ropinirole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether ropinirole passes into breast milk or if it could affect the nursing baby. Ropinirole may slow breast milk production. Tell your doctor if you are breast-feeding. Ropinirole is not approved for use by anyone younger than 18 years old. How should I take ropinirole? Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you are taking immediate-release ropinirole (Requip) you should not take extended-release ropinirole (Requip XL) at the same time. The dose and timing of ropinirole in treating Parkinson's disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label. Ask your pharmacist if you have any questions about the kind of ropinirole you receive at the pharmacy. Ropinirole can be taken with or without food. Take the medicine at the same time each day. Do not crush, chew, or break an extended-release tablet (Requip XL). Swallow it whole. Call your doctor if you see part of the ropinirole tablet in your stool. This is a sign that your body may not have absorbed all of the medicine. If you are taking this medicine for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Do not stop using ropinirole suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking ropinirole? Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Dizziness may impair your thinking or reactions. Avoid driving or operating machinery until you know how ropinirole will affect you. Drinking alcohol can increase certain side effects of ropinirole. Ropinirole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Some people taking ropinirole have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Call your doctor at once if you have: extreme drowsiness, falling asleep suddenly (even after feeling alert); worsening or no improvement in your symptoms; a light-headed feeling, like you might pass out; unusual changes in mood or behavior; tremors, twitching uncontrollable muscle movements; or hallucinations (seeing or hearing things that are not real). Side effects such as confusion or hallucinations may be more likely in older adults. Common side effects may include: drowsiness, dizziness, weakness; headache, confusion, hallucinations; increased blood pressure (severe headache, pounding in your neck or ears, nosebleed, irregular heartbeats); nausea, vomiting, upset stomach, constipation; flu symptoms (fever, chills, body aches); sudden muscle movements; increased sweating; or swelling in your legs or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect ropinirole? Taking ropinirole with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures. Other drugs may interact with ropinirole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is rosuvastatin? Rosuvastatin is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Rosuvastatin is also used to treat hereditary types of high cholesterol (hypercholesterolemia): The heterozygous type (inherited from one parent) or the homozygous type (inherited from both parents). For the heterozygous type, rosuvastatin can be used in children who are at least 8 years old. For the homozygous type, rosuvastatin can be used in children as young as 7 years old. The Ezallor brand of rosuvastatin is for use only in adults. Crestor is also used in adults to slow the progression of atherosclerosis (a build-up of plaque in blood vessels that can block blood flow). Crestor is also used to lower the risk of stroke, heart attack, and other complications in men 50 years and older or women 60 years and older who have coronary heart disease or other risk factors. Rosuvastatin may also be used for purposes not listed in this medication guide. Warnings Do not use rosuvastatin if you are pregnant. It could harm the unborn baby. You should not take rosuvastatin if you have liver disease, or if you breastfeeding a baby. Before taking this medicine You should not take rosuvastatin if you are allergic to it, or if you have: liver disease; or if you are pregnant or breast-feeding. Do not take rosuvastatin if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are taking rosuvastatin. Stop taking rosuvastatin and tell your doctor right away if you become pregnant. Do not breastfeed while you are taking rosuvastatin. Tell your doctor if you have ever had: liver problems; kidney disease; a thyroid disorder; a habit of drinking more than 2 alcoholic beverages per day; if you are of Asian descent; or if you are 65 or older. Rosuvastatin can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). People of Asian descent may absorb rosuvastatin at a higher rate than other people. Make sure your doctor knows if you are Asian. You may need a lower than normal starting dose. How should I take rosuvastatin? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Rosuvastatin is usually taken once a day, with or without food. Take the medicine at the same time each day. While using rosuvastatin, you may need frequent blood tests. Keep using rosuvastatin as directed, even if you feel well. High cholesterol usually has no symptoms. You may need to take rosuvastatin on a long-term basis. You may need to stop using rosuvastatin for a short time if you have: uncontrolled seizures; an electrolyte imbalance (such as high or low potassium levels in your blood); severely low blood pressure; a severe infection or illness; dehydration; or surgery or a medical emergency. You should not stop using rosuvastatin unless your doctor tells you to. Rosuvastatin is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking rosuvastatin? Avoid eating foods high in fat or cholesterol, or rosuvastatin will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Some antacids can make it harder for your body to absorb rosuvastatin. Avoid taking an antacid that contains aluminum or magnesium within 2 hours after taking rosuvastatin. Rosuvastatin side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: unexplained muscle pain, tenderness, or weakness; muscle weakness in your hips, shoulders, neck, and back; trouble lifting your arms, trouble climbing or standing; confusion, memory problems; or liver problems--upper stomach pain, tiredness, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes). Common side effects may include: headache; weakness; muscle aches; or nausea, stomach pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect rosuvastatin? When you start or stop taking rosuvastatin, your doctor may need to adjust the doses of any other medicines you take on a regular basis. Using certain medicines together with rosuvastatin can increase your risk of serious muscle problems. It is very important to tell your doctor about all medicines you use, and those you start or stop using during your treatment with rosuvastatin, especially: colchicine; cyclosporine; antifungal medicine--fluconazole, itraconazole, ketoconazole; antiviral medicine to treat HIV or hepatitis C--atazanavir, fosamprenavir, ledipasvir, lopinavir, ritonavir, simeprevir, sofosbuvir, tipranavir, Epclusa, Mavyret, Viekira, Vosevi, and others; a blood thinner--warfarin, Coumadin, Jantoven; cancer medicine--darolutamide, regorafenib; medicines that contain niacin or nicotinic acid--vitamin B3, Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others; or other cholesterol medications--fenofibrate, gemfibrozil. This list is not complete. Other drugs may affect rosuvastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is rufinamide? Rufinamide is a seizure medication, also called an anti-epileptic or anticonvulsant. Rufinamide is used together with other medicines to treat seizures caused by Lennox-Gastaut syndrome, a severe form of childhood epilepsy that also causes developmental and behavior problems. Rufinamide is for use in adults and children who are at least 1 year old. Rufinamide may also be used for purposes not listed in this medication guide. Warnings You should not use rufinamide if you have a severe liver disease, or a genetic heart rhythm disorder called short QT syndrome. You should not stop taking rufinamide suddenly, unless your doctor tells you to stop the medicine because of a serious side effect. Some people have thoughts about suicide while taking seizure medication. Stay alert to changes in your mood or symptoms. Before taking this medicine You should not use rufinamide if you are allergic to it, or if you have: a genetic heart rhythm disorder called short QT syndrome; or severe liver disease. Tell your doctor if you have ever had: heart disease; liver disease; kidney disease (or if you are on dialysis); or depression, mental illness, or suicidal thoughts or actions. Some people have thoughts about suicide while taking rufinamide. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of rufinamide on the baby. Rufinamide can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using rufinamide, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Rufinamide should not be given to a child younger than 1 year old. How should I take rufinamide? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take rufinamide with food. The rufinamide tablet may be swallowed whole, crushed, or cut in half. Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid using the dosing syringe and bottle adapter provided with rufinamide. Insert the adapter into the bottle and snap it into place. Insert the syringe into the adapter and turn the bottle upside down. To measure your dose, pull the plunger to the correct number of milliliters marked on the side of the syringe. Rinse the syringe with water after each use. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Call your doctor if your seizures get worse or you have them more often while taking rufinamide. You should not stop using rufinamide suddenly, unless your doctor tells you to stop the medicine because of a serious side effect. Stopping suddenly may cause increased seizures. Follow your doctor's instructions very carefully. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Store the liquid medicine in an upright position. Do not try to remove the bottle adapter once it is in place. Throw away rufinamide liquid 90 days after you first opened the bottle, even if there is medicine left inside. In case of emergency, wear or carry medical identification to let others know you use rufinamide. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking rufinamide? Avoid driving or hazardous activity until you know how rufinamide will affect you. Your reactions could be impaired. Drinking alcohol can increase certain side effects of rufinamide. Rufinamide side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, agitated, hostile, aggressive, restless, irritable, hyperactive, talkative, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: loss of balance or coordination; trouble walking; or worsening or increased seizures. Common side effects may include: headache; dizziness, drowsiness; nausea; or feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Rufinamide dosing information Usual Adult Dose for Lennox-Gastaut Syndrome: Initial dose: 400 to 800 mg orally per day in 2 equally divided doses -Titrate in 400 to 800 mg increments every other day until a maximum daily dose of 3200 mg/day is reached Maintenance dose: 1600 mg orally twice a day Comments: -It is not known if doses lower than 3200 mg/day are effective. -For patients concomitantly receiving valproate, initial doses should be lower; see dose adjustments section. Use: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome. Usual Pediatric Dose for Lennox-Gastaut Syndrome: 1 year of age or older: Initial dose: 10 mg/kg/day orally in 2 equally divided doses -Titrate in 10 mg/kg increments every other day to a target dose of 45 mg/kg/day Maintenance dose: 45 mg/kg orally per day in 2 equally divided doses Maximum dose: 3200 mg/day Comments: -It is not known if doses lower than 45 mg/kg (not to exceed 3200 mg/day) are effective. -For patients concomitantly receiving valproate, initial doses should be lower; see dose adjustments section. Use: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in pediatric patients 1 year of age and older   What other drugs will affect rufinamide? Using rufinamide with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: valproic acid (Depakene, Stavzor). This list is not complete. Other drugs may affect rufinamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is Salagen? Salagen affects the nervous system and increases saliva secretion in the mouth. Salagen is used to treat dry mouth caused by Sjogren's syndrome, or by radiation to treat head and neck cancer. Salagen may also be used for purposes not listed in this medication guide. Warnings You should not use Salagen if you have narrow-angle glaucoma, or asthma that is untreated or uncontrolled. Before taking this medicine You should not use Salagen if you are allergic to it, or if you have: untreated or uncontrolled asthma; or narrow-angle glaucoma. To make sure Salagen is safe for you, tell your doctor if you have: asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD), or other breathing disorder; glaucoma or vision problems; liver disease; kidney disease; heart disease; gallbladder problems; mental illness; if you take heart or blood pressure medicine; or if you use a bronchodilator to treat a breathing disorder. FDA pregnancy category C. It is not known whether Salagen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Salagen. It is not known whether pilocarpine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take Salagen? Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take Salagen with or without food. Drink plenty of liquids while you are taking Salagen. This medicine can cause increased sweating and you may get dehydrated easily. Use Salagen regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Salagen can be fatal at very high doses. What should I avoid while taking pilocarpine? Salagen may cause blurred vision, especially at night or in low light. Be careful if you drive or do anything that requires you to be able to see clearly. Avoid becoming overheated during exercise and in hot weather. Salagen can increase sweating and you may be more prone to dehydration. Salagen side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Salagen and call your doctor at once if you have: shortness of breath; fast or slow heart rate; severe headache, pounding in your neck or ears; confusion, tremors; or a light-headed feeling, like you might pass out. Common side effects may include: increased sweating, urinating more than usual; chills, or flushing (warmth, redness, or tingly feeling); headache, dizziness, weakness; nausea, vomiting, diarrhea; blurred vision, watery eyes; or runny nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Salagen? Other drugs may interact with pilocarpine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using

What is sertraline? Sertraline is an antidepressant that belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Sertraline is used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder (SAD), and post-traumatic stress disorder (PTSD). Sertraline is also used to treat premenstrual dysphoric disorder. Warnings You should not use sertraline if you also take pimozide, or if you are being treated with methylene blue injection. Do not use sertraline if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some children and young adults have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Before taking this medicine You should not use sertraline if you are allergic to it, or if you also take pimozide. Do not use the liquid form of this medicine if you take disulfiram (Antabuse). Do not use sertraline within 14 days before or 14 days after using an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with sertraline could cause a serious condition called serotonin syndrome. To make sure sertraline is safe for you, tell your doctor if you have ever had: bipolar disorder (manic depression); heart disease, high blood pressure, or a stroke; liver or kidney disease; seizures; glaucoma; bleeding problems, or if you take warfarin (Coumadin, Jantoven); long QT syndrome; or low levels of sodium in your blood. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Sertraline is approved for use in children at least 6 years old, only to treat obsessive-compulsive disorder but not depression. Taking sertraline during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop this medicine without asking your doctor. Ask a doctor if it is safe to breastfeed while using this medicine. How should I take sertraline? Take sertraline exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Take sertraline with or without food, at the same time each day. Sertraline liquid (oral concentrate) must be diluted with a liquid right before you take it. Read and carefully follow all mixing instructions provided with your medicine. Ask your doctor or pharmacist if you need help. Measure the mixed medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). Sertraline may cause false results on a drug-screening urine test. Tell the laboratory staff that you use this medicine. Do not stop using sertraline suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine. Store tightly closed at room temperature, away from moisture and heat. Dosing information Usual Adult Dose for Depression: Initial dose: 50 mg orally once a day Maintenance Dose: 50 to 200 mg orally once a day. Usual Adult Dose for Obsessive Compulsive Disorder: Initial dose: 50 mg orally once a day Maintenance Dose: 50 to 200 mg orally once a day Usual Adult Dose for Panic Disorder: Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day Maintenance dose: 50 to 200 mg orally once a day. Usual Adult Dose for Post Traumatic Stress Disorder: Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day Maintenance dose: 50 to 200 mg orally once a day Usual Adult Dose for Social Anxiety Disorder: Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day Maintenance dose: 50 to 200 mg orally once a day. Usual Adult Dose for Premenstrual Dysphoric Disorder: Continuous regimen: -Initial dose: 50 mg orally once a day during the menstrual cycle -Maintenance dose: 50 to 150 mg orally once a day during the menstrual cycle Cyclic regimen: -Initial dose: 50 mg orally once a day starting 14 days prior to the anticipated start of menstruation through to the first full day of menses, and repeated with each new cycle -Maintenance dose: 50 to 100 mg orally once a day. Usual Pediatric Dose for Obsessive Compulsive Disorder: 6 to 12 years: -Initial dose: 25 mg orally once a day -Maintenance dose: 25 to 200 mg orally once a day 13 to 17 years: -Initial dose: 50 mg orally once a day -Maintenance dose: 50 to 200 mg orally once a day.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking sertraline? Drinking alcohol with sertraline can cause side effects. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Sertraline side effects Get emergency medical help if you have signs of an allergic reaction to sertraline: skin rash or hives (with or without fever or joint pain); difficulty breathing; swelling of your face, lips, tongue, or throat. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a seizure; vision changes, eye pain, redness, or swelling; low blood sodium - headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or manic episodes - racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Sertraline can affect growth in children. Your child's height and weight may be checked often. Common sertraline side effects may include: indigestion, nausea, diarrhea, loss of appetite; sweating; tremors; or sexual problems. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sertraline? Sertraline can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with sertraline may cause you to bruise or bleed easily. Other drugs may interact with sertraline, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is sevelamer? Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus. Sevelamer is used to control phosphorus levels in people with chronic kidney disease who are on dialysis. Sevelamer may also be used for purposes not listed in this medication guide. Warnings You should not take sevelamer if you have a bowel obstruction. Before taking this medicine You should not take sevelamer if you are allergic to it, or if you have a bowel obstruction. To make sure sevelamer is safe for you, tell your doctor if you have: trouble swallowing; severe constipation; a blockage in your intestines; slow digestion; a stomach or intestinal disorder; or if you have recently had stomach or intestinal surgery. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Your dose needs may be different during pregnancy. Taking sevelamer while you are pregnant can lower your blood levels of certain vitamins or folic acid. Follow your doctor's instructions about taking vitamins or mineral supplements during pregnancy. Because sevelamer is not absorbed into the bloodstream, it is not expected to be harmful to a nursing baby. Sevelamer is not approved for use by anyone younger than 6 years old. How should I take sevelamer? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use sevelamer in larger or smaller amounts or for longer than recommended. Take sevelamer with meals. Sevelamer powder must be dissolved in water before you take it. The 0.8-gram packet should be mixed with at least 1 ounce (2 tablespoons) of water. The 2.4-gram packet should be mixed with at least 2 ounces (4 tablespoons) of water. Stir the powder in water until it is completely dissolved. Stir and drink this mixture right away. To get the entire dose, add a little more water to the same glass, swirl gently and drink right away. While using sevelamer, you may need frequent blood tests. Call your doctor if you have have trouble swallowing the tablet, or if it feels like it gets stuck in your esophagus after you swallow it. Sevelamer may be only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must eat or avoid to help control your condition. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Be sure to take the missed dose with food. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking sevelamer? You may be taking other medicines that should not be taken at the same time. Taking sevelamer can make it harder for your body to absorb certain drugs, making them less effective: ciprofloxacin (Cipro) should be taken at least 2 hours before or 6 hours after you take sevelamer; mycophenolate mofetil (CellCept) should be taken at least 2 hours before you take sevelamer. Sevelamer side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using sevelamer and call your doctor at once if you have: choking, or trouble swallowing; black, bloody, or tarry stools; severe constipation with stomach pain; or constipation that gets worse or does not clear up. Common side effects may include: nausea, vomiting, stomach pain, loss of appetite; upset stomach, gas, bloating; diarrhea, constipation; tired feeling; itching; or joint pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Sevelamer dosing information Usual Adult Dose for Hyperphosphatemia of Renal Failure: Initial Dosing for patients not on a phosphate binder: 800 mg to 1600 mg orally 3 times a day with meals Based on serum phosphorus level: -Phosphorus greater than 5.5 to less than 7.5 mg/dL: 800 mg 3 times a day with meals -Phosphorus greater than or equal to 7.5 mg/dL: 1600 mg 3 times a day with meals -Titrate in increments of 800 mg 3 times a day at 2-week intervals with the goal of controlling serum phosphorus within target range. Average prescribed dose: 7.2 g/day (2.4 g with each meal) Maximum studied dose: 14 g per day (carbonate); 13 g per day (hydrochloride) Switching from the hydrochloride salt to carbonate: Use the same dose, however further titration may be necessary to achieve desired phosphorus levels. Switching from calcium acetate: Substitute approximately mg for mg Comment: Treatment of hyperphosphatemia includes reduction in dietary intake of phosphate, inhibition of intestinal phosphate absorption with phosphate binders, and removal of phosphate with dialysis. Use: To control serum phosphorus levels in patients with chronic kidney disease on dialysis.   What other drugs will affect sevelamer? Other drugs may interact with sevelamer, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is sildenafil? Sildenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take Viagra while also taking Revatio. Warnings Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). Do not take sildenafil with riociguat. Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis. Stop using sildenafil and get emergency medical help if you have sudden vision loss. Before taking this medicine You should not use sildenafil if you are allergic to it, or: if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas). Do not take this medicine if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. To make sure sildenafil is safe for you, tell your doctor if you have ever had: heart problems (chest pain, a heart rhythm disorder, heart attack); high or low blood pressure; blood circulation problems; retinitis pigmentosa (an inherited condition of the eye); blindness in one or both eyes; bleeding problems; a stomach ulcer; pulmonary veno-occlusive disease (PVOD); liver or kidney disease; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a physical deformity of the penis (such as Peyronie's disease); or if you have been told you should not have sexual intercourse for health reasons. Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. It is not clear whether this medicine is the actual cause of vision loss. This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor. It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor. Do not give this medication to anyone under 18 years old without medical advice. How should I take sildenafil? Take sildenafil exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Revatio is usually taken three times each day, about 4 to 6 hours apart. Viagra is usually taken only when needed, 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Do not take Viagra more than once per day. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Viagra can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of sildenafil. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Since Viagra is used as needed, you are not likely to miss a dose. If you miss a dose of Revatio, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol with sildenafil can cause side effects. Grapefruit may interact with sildenafil and lead to unwanted side effects. Avoid the use of grapefruit products. Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor. Sildenafil side effects Get emergency medical help if you have signs of an allergic reaction to sildenafil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sildenafil and get emergency medical help if you have: heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; vision changes or sudden vision loss; erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis); ringing in your ears, or sudden hearing loss; irregular heartbeat; swelling in your hands, ankles, or feet; shortness of breath; seizure (convulsions); or a light-headed feeling, like you might pass out. Common sildenafil side effects may include: flushing (warmth, redness, or tingly feeling); headache, dizziness; heartburn, nausea, or upset stomach abnormal vision (blurred vision, changes in color vision) runny or stuffy nose, nosebleeds; sleep problems (insomnia); or muscle pain, back pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sildenafil? Do not take sildenafil with similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra). Tell your doctor about all other medications you use for erectile dysfunction. Do not take sildenafil if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas). Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. In addition, tell your doctor about all your other medicines, especially: drugs to treat high blood pressure or a prostate disorder; antifungal medicine - ketoconazole or itraconazole; or medicine to treat HIV/AIDS - ritonavir and others. This list is not complete. Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is silodosin? Silodosin is an alpha-blocker that is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate). Silodosin may also be used for purposes not listed in this medication guide. Warnings Tell your doctor about all your other medicines. Some drugs should not be used with silodosin. Before taking this medicine You should not take silodosin if you are allergic to it, or if you have: severe liver disease; or severe kidney disease. Some drugs should not be used with silodosin. Your treatment plan may change if you also use: nefazodone; an antibiotic--clarithromycin, telithromycin; antifungal medicine--itraconazole, ketoconazole, posaconazole, voriconazole; or antiviral medicine for HIV or hepatitis C--boceprevir, cobicistat, dasabuvir, elvitegravir, indinavir, lopinavir/ritonavir, nelfinavir, ombitasvir, paritaprevir saquinavir, telaprevir, or tipranavir. Tell your doctor if you have ever had: low blood pressure; kidney disease (or if you are on dialysis); heart disease; prostate cancer; a condition for which you take a diuretic or "water pill"; or if you are on a low-salt diet. Silodosin can affect your pupils. If you need eye surgery, tell the surgeon about your use of silodosin, even if you no longer take it. Silodosin is not for use in women, and the effects of this medicine during pregnancy or in breastfeeding women are unknown. Not approved for use by anyone younger than 18 years old. How should I take silodosin? Your doctor may test your prostate specific antigen (PSA) to check for prostate cancer before you take silodosin. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take once daily with a meal. If you cannot swallow a capsule whole, open it and mix the medicine with applesauce. Swallow the mixture right away without chewing. Your blood pressure may get too low during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea. Your blood pressure will need to be checked often. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking silodosin? Avoid driving or hazardous activity until you know how silodosin will affect you. Your reactions could be impaired. Silodosin side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe dizziness, or if you feel like you might pass out. Silodosin may cause dizziness or fainting, especially when you first start taking it. You may feel very dizzy when you first wake up or get up too fast from a sitting or lying position. Common side effects may include: dizziness, feeling like you might pass out; headache; diarrhea; abnormal ejaculation; or stuffy nose, sinus pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Silodosin dosing information Usual Adult Dose for Benign Prostatic Hyperplasia: 8 mg orally once a day with a meal Comments: Patients who have difficulty swallowing may open the capsule and sprinkle the powder on a tablespoonful of applesauce. The applesauce should not be hot, and should be soft enough to be swallowed within 5 minutes without chewing and followed with 8 ounces of cool water.   What other drugs will affect silodosin? Tell your doctor about all your current medicines. Many drugs can increase your risk of very low blood pressure while taking silodosin, especially: medicines similar to silodosin (alfuzosin, doxazosin, prazosin, tamsulosin, or terazosin); heart or blood pressure medication; or sildenafil (Viagra) and other erectile dysfunction medicines. This list is not complete and many other drugs may affect silodosin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is simvastatin? Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors. Simvastatin is used in adults and children who are at least 10 years old. Warnings In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Never take simvastatin in larger amounts, or for longer than recommended by your doctor. Follow your doctor's dosing instructions very carefully. Taking too much of this medication may cause serious or life-threatening side effects. Before taking this medicine, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily. Simvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant or planning to become pregnant. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not consume grapefruit products while taking this medication. Some medicines can cause unwanted or dangerous effects when used with simvastatin. Your doctor may need to change your treatment plan if you use certain antibiotics or antifungal medicines, hepatitis C medication, heart medication, or medicines to treat HIV/AIDS. Stop taking this medication and tell your doctor right away if you become pregnant. Before taking this medicine You should not take this medicine if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease. The following drugs can increase your risk of serious muscle problems if you take them together with simvastatin. These drugs should not be used while you are taking this medicine: cyclosporine; danazol; gemfibrozil; nefazodone; an antibiotic - clarithromycin, erythromycin, telithromycin; antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole; hepatitis C medications - boceprevir, telaprevir; or HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir. Before you start taking simvastatin, tell your doctor if you are already using any of these other medicines: lomitapide; or heart medication - amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil. To make sure simvastatin is safe for you, tell your doctor if you have: history of liver disease; history of kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily. Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take simvastatin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine. Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking this medicine.   How should I take simvastatin? Take simvastatin exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects. Simvastatin is usually taken at bedtime or with an evening meal. If you take simvastatin more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results. While using simvastatin, you may need frequent blood tests at your doctor's office. You may need to take simvastatin on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to. Simvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine. Avoid eating foods that are high in fat or cholesterol. Simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Simvastatin side effects Get emergency medical help if you have any of these signs of an allergic reaction to simvastatin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor at once if you have: signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or muscle weakness in your hips, shoulders, neck, and back; trouble lifting your arms, trouble climbing or standing; or liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common simvastatin side effects may include: headache; constipation, nausea, stomach pain; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect simvastatin? Many drugs can interact with simvastatin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment, especially: delavirdine; fenofibrate; or fluconazole. This list is not complete and many other drugs can interact with simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

What is solifenacin? Solifenacin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage). Solifenacin oral suspension (liquid), Vesicare LS is used to treat overactive bladder caused by a neurologic disorder (such as multiple sclerosis or spinal cord injury) in children at least 2 years old when other medicines cannot be used or have not worked. Solifenacin may also be used for purposes not listed in this medication guide. Warnings You should not use solifenacin if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate. Before taking this medicine You should not use solifenacin if you are allergic to it, or if you have: untreated or uncontrolled narrow-angle glaucoma; a stomach disorder causing delayed emptying; or if you are unable to urinate. Tell your doctor if you have ever had: glaucoma; liver disease; kidney disease; trouble emptying your bladder (or you have a weak stream of urine); slow digestion; a blockage in your stomach or intestines; or long QT syndrome. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using solifenacin. How should I take solifenacin? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Solifenacin is usually taken once per day with or without food. Follow your doctor's instructions. Do not crush, chew, or break the tablet. Swallow it whole. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Take the tablet with water. After taking solifenacin liquid drink a glass of water or milk. Avoid taking the liquid with food or other drinks or you may have a bitter aftertaste. Store solifenacin in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use. Throw away any unused liquid 28 days after you first opened the bottle. What happens if I miss a dose? Tablets: Skip the missed dose and use your next dose at the regular time. Do not take 2 doses on the same day. Oral suspension: Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking solifenacin? Avoid driving or hazardous activity until you know how solifenacin will affect you. Your reactions could be impaired. Avoid becoming overheated or dehydrated during exercise and in hot weather. Solifenacin can decrease perspiration and you may be more prone to heat stroke. Solifenacin side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Stop using solifenacin and call your doctor at once if you have: severe stomach pain, or constipation for 3 days or longer; pain or burning when you urinate; headache, confusion, drowsiness, hallucinations; vision changes, eye pain, or seeing halos around lights; little or no urination, pain or burning when you urinate; dehydration symptoms--dizziness, tiredness, feeling very thirsty or hot, decreased sweating, or hot and dry skin; or high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: blurred vision; dry mouth, dry eyes; painful urination; constipation; or heat stroke--decreased sweating, dry skin, dizziness, tiredness, nausea, feeling hot. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Solifenacin dosing information Usual Adult Dose for Urinary Incontinence: Initial dose: 5 mg orally once daily Maintenance dose: 5 to 10 mg orally once daily Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency Usual Adult Dose for Urinary Frequency: Initial dose: 5 mg orally once daily Maintenance dose: 5 to 10 mg orally once daily Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency   What other drugs will affect solifenacin? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can affect solifenacin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.